378 Aspirin Desensitization Treatment

378 Aspirin Desensitization Treatment: A Case Report

School of Marilia, São Paulo, Brazil; Flow Citometry, and; Dermatology, Medical School of Marilia, Marilia, Brazil. Background: The prevalence of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is high and its in vitro diagnostic is a challenge. The basophil activation test with determination by flow cytometry (FC), of the expression rate of CD63 molecules has been much studie...

Aspirin desensitization for urgent endovascular treatment of the aneurysm

Hypersensitivity reactions to aspirin (acetylsalicylic acidASA) and other nonsteroidal anti-inflammatory drugs (NSAIDs) constitute only a subset of all adverse reactions to these drugs, but due to their severity they pose a significant risk to patients. The authors report a case of a 48 year old woman with asthma, hypertension, obstructive sleep apnea and a NSAIDs-exacerbated respiratory diseas...

Aspirin Desensitization in Samter’s Triad

Samter’s triad (ST) is a syndrome characterized with asthma, nasal polyposis (NP) and rhinosinusitis, in which the patients are unable to tolerate aspirin and aspirin-like drugs. NP often accompanies the existing disease in patients with aspirin intolerance (AI) [1]. Topical and systemic steroids are used for the treatment of rhinitis and polyps. Antihistamines and chromons do not seem to have ...

Individual monitoring of aspirin desensitization.

BACKGROUND Patients with aspirin-sensitive rhinosinusitis, which is frequently associated with intrinsic bronchial asthma, can be desensitized by long-term treatment with oral aspirin. The exact mechanisms of this desensitization remain obscure, but modulations of the eicosanoid pathway occur and can be monitored with the help of a practicable in vitro assay on mixed leukocyte cultures. OBJEC...

Aspirin desensitization achieved after omalizumab treatment in a patient with aspirin-exacerbated urticaria and respiratory disease.